Triplex-forming PNA modified with unnatural nucleobases: the role of protonation entropy in RNA binding.
نویسندگان
چکیده
Peptide nucleic acid (PNA) modified with unnatural nucleobases enables the formation of a highly stable triplex with a double-stranded RNA at physiological pH. In this communication, we evaluated kinetics and thermodynamics of PNA/RNA triplex formation as a function of both pH and temperature. Protonation entropy was found to be the major factor responsible for the destabilization of the triplex and for the progressive decrease in the association rate at more basic pHs.
منابع مشابه
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ورودعنوان ژورنال:
- Physical chemistry chemical physics : PCCP
دوره 18 47 شماره
صفحات -
تاریخ انتشار 2016